People / Talamo Laboratory

Contact

Barbara R. Talamo, Ph.D., Professor of Neuroscience
Office Phone: (617) 636-3639
Lab Phone: (617) 636-3647
Fax: (617) 636-2413
barbara.talamo@tufts.edu

Search for recent publications by Barbara Talamo

Research Interests

My laboratory has a long standing interest in cellular signaling, focusing on second messenger systems and their long-term regulation by extrinsic signals derived from other cells and by previous events in the same cell. Additional interests include the pathobiology of Alzheimer's disease and neurodegeneration, focusing on features that contribute to pathological modes of transdifferentiation and cell death in the peripheral olfactory system.

Laboratory Projects

• Receptor-mediated signaling in rat parotid acinar cells
• Olfactory receptor cell sensitivity to activation
• Alzheimer's disease and neurodegenerative diseases

Selected Publications

"Pathological changes in olfactory neurons in patients with Alzheimer's disease" B.R. Talamo, R.A. Rudel, K.S. Kosik, V.M-Y. Lee, S. Neff, L. Adelman, and J.S. Kauer, Nature, 337:736-739 (1989).

"Sphingosine, W-7 and trifluoperazine inhibit the elevation in cytosolic calcium induced by high K+ depolarization in synaptosomes" M. Sitges and B.R. Talamo J. Neurochem. 61:443-450 (1993).

"Modulation of extracellular ATP-activated calcium influx in rat parotid acinar cells" L. Tenneti and B.R. Talamo, Biochem. J. 295:255-261 (1993).

"Human Olfactory Epithelium: Normal Patterns and Types of Lesions Found in the General Population." B.R. Talamo, W.-H. Feng, M. Stockmayer. Inhalation Toxicol. 6:249-275 (1994).

"Early diagnosis of Alzheimer’s?" B.R. Talamo (Scientific Correspondence), Nature, 369:365-366 (1994).

"New Structure in Human Olfactory Epithelium: The Olfactory Pit" W.-H. Feng, J.S. Kauer, L.Adelman and B.R. Talamo, J. Comparative Neurology, 378:443-453 1997. [Follow this link for image of the olfactory pit].

"Expression and Trans-synaptic Regulation of P_2x4 and P_2z Receptors for Extracellular ATP in Parotid Acinar Cells: Effects of Parasympathetic Denervation", L. Tenneti, S. Gibbons and B.R. Talamo, J. Biol. Chem, 273: 26799-26808 (1998).

"Antisense Oligonucleotides, Strategies and Successes", B.R. Talamo, Chemical Senses 23:241-242 (1998).

"Introduction. Antisense Oligonucleotides, Strategies and Successes" B.R. Talamo, Chemical Senses, 23: 243-247 (1998).

"Salivary Gland P2 Nucleotide Receptors", invited review. J.T. Turner, L.A. Landon, S.J. Gibbons and B.R. Talamo, Critical Rev. in Oral Biol. and Med., 10: 210-224 (1999).

"Neuroscience training at the turn of the century: a summary report of the third annual ANDP survey", R. Ranney Mize, Barbara R. Talamo, Ronald I. Schoenfeld, Lesly K. Huffman, and Robert E. Fellows, Nature Neuroscience 3: 433-435 (2000).

"P2X7 (P2Z) Receptors in Rat Parotid Acinar Cells: Formation of Large Pores ", Simon J. Gibbons, Katrina Washburn, and Barbara R. Talamo, J. Auton Pharmacol; 21(4):181-190 (2001).

"Comparison of Mechanical Agitation and Calcium Shock Methods for Preparation of a Membrane Fraction Enriched in Olfactory Cilia", Katrina B. Washburn, Timothy J. Turner, and Barbara R. Talamo, Chem. Senses 27: 635-642 (2002)