People / Vetter Laboratory

Contact

Douglas E. Vetter, Ph.D.
Assistant Professor of Neuroscience
Office Phone: (617) 636-3643
Lab Phone: (617) 636-3478
Fax: 617-636-2413
Email: douglas.vetter@tufts.edu

Search for recent publications by Douglas E. Vetter

Research Interests

Peripheral auditory processing and auditory physiology; molecular biology of neurotransmitter receptors; protein:protein interactions; intracellular signaling pathways; growth cone differentiation and synapse formation; transgenic mouse production.

For more information please see the Vetter Lab Research Description.

Lab Members and Projects

• Vidya Murthy, Neuroscience Graduate Student- nicotinic receptors and
  their role in inner ear development and function.
• Christine Graham, Neuroscience Graduate Student- CRH receptors and their
  role in inner ear development and function.
• Sevin Turcan, Biomedical Engineering Graduate Student- bioinformatic
  modeling (including Bayesian network analysis) of gene and protein
  expression changes in the inner ear following targeted deletion of
  nicotinic and CRH receptors.
• Julian Taranda, visiting Graduate student from Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina- nicotinic receptor roles in inner ear development and olivocochlear function.

Recent Publications

Vetter D.E., Katz, E., Maison, S.F., Taranda, J., Turcan, S., Ballestero, J., Liberman, M.C., Elgoyhen, A.B., and Boulter, J. The alpha10 nicotinic acetylcholine receptor subunit is required for normal function and development of olivocochlear innervation. PNAS. In Press

Chernyavskyy, A.I., Arredondo, J., Vetter, D.E., and Grando, S.A. (2007) Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization.  Exp. Cell. Res. 2007 Oct 1; 313(16): 3542-55.

Maison S.F., Vetter D.E., Liberman M.C. (2007) A novel effect of cochlear efferents: in vivo response enhancement does not require α9 cholinergic receptors. J Neurophysiol. 97:3269-78.

Sage C, Huang M, Vollrath MA, Brown MC, Hinds PW, Corey DP, Vetter DE, Chen ZY (2006) Essential role of retinoblastoma protein in mammalian hair cell development and hearing. Proc Natl Acad Sci U S A. May 9;103(19):7345-50.

Katz, E., Elgoyhen, A.B., Gomez-Casati, M.E., Knipper, M., Vetter, D.E., Fuchs, P.A., and Glowatzki, E. (2004) Developmental regulation of nicotinic synapses on cochlear inner hair cells. J. Neurosci., 24(36):7814-7820.

He, D.Z.Z., Cheatham, M.A., Pearce, M., and Vetter, D.E.  (2004)  Mouse outer hair cells lacking the alpha9 ACh receptor are motile.  Dev. Br. Res. 148:19-25.

Nguyen, V-T., Chernyavsky, A.I., Arredondo, J., Bercovich, D., Orr-Urtreger, A., Vetter, D.E., Wess, J., Beaudet, A.L., Kitajima, Y., Grando, S.A.  (2004)  Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes.  Exp. Cell Res. 294:534-549.

Arredondo, J. , Nguyen, V-T., Chernyavsky, A.I., Bercovich, D. , Orr-Urtreger, Vetter, D.E., and Grando. S.A.  (2003)  Functional role of a7 nicotinic receptor in physiological control of cutaneous homeostasis.  Life Sciences, 72: 2063-2067.

J. Arredondo, V-T. Nguyen, A.I. Chernyavsky, D. Bercovich, A. Orr-Urtreger, W. Kummer, K. Lips, D.E. Vetter, and S.A. Grando (2002) Central Role of alpha7 Nicotinic Receptor in Differentiation of the Stratified Squamous Epithelium. J. Cell Biol. 159(2): 325-336.

Vetter, D.E., Li, C., Zhou, L., Contarino, A., Liberman, M.C., Smith, G.W., Marchuk, Y., Koob, G.F., Heinemann, S.F., Vale, W., Lee, K-F. (2002) Urocortin-deficit mice display hearing impairments and increased anxiety-like activity. Nat. Gen. 31: 363-369.

May, B.J., Prosen, C.A., Weiss, D., and Vetter, D.E. (2002) Behavioral investigation of some possible effects of the central olivocochlear pathways in transgenic mice. Hearing Res., 171: 143-58.

Weisstaub, N., Vetter, D.E., Elgoyhen, A.B., Katz, E. (2002) The a9a10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cations. Hearing Res. 167: 122-35.

Elgoyhen, A.B., Vetter, D.E., Katz, E., Rothlin, C.R., Heinemann, S.F., and Boulter, J. (2001) Alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc. Natl. Acad. Sci. USA 98: 3501-3506.

Prosen, C.A., Bath, K.G., Vetter D.E., and May, B.J. (2000) Behavioral assessments of auditory sensitivity in transgenic mice. J. Neurosci. Methods 97: 59-67.

Katz, E., Verbitsky, M., Rothlin, C.V., Vetter, D.E., Heinemann, S.F., and Belen, E.A. (2000) High calcium permeability and calcium block of the alpha9 nicotinic acetylcholine receptor. Hearing.Research 141: 117-128.

Rothlin, C.V., Katz, E., Verbitsky, M., Vetter, D.E., Heinemann, S.F., and Elgoyhen, A.B. (2000) Block of the alpha9 nicotinic receptor by ototoxic aminoglycosides. Neuropharmacology 39: 2525-2532.

Vetter, D.E., Liberman, M.C., Mann, J., Barhanin, J., Boulter, J., Brown, M.C., Saffiote-Kolman, J., Heinemann, S.F., and Elgoyhen, A.B. (1999) Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron 23: 93-103.

Somia, N.V., Schmitt, M.J., Vetter, D.E., Van Antwerp, D., Heinemann, S.F., and Verma, I.M. (1999) LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell death. Proc Natl Acad Sci USA 96: 12667-12672.

Vetter, D.E., Mann, J.R., Wangemann, P., Liu, J., Mclaughlin, K.J., Lesgae, F., Marcus, D.C., Lazdunski, M. Heinemann, S.F., and Barhanin, J. (1996) Inner ear defects induced by null mutation of the isk gene. Neuron 17: 1251-1264.