People

Lakshmanan (Lax) Iyer, Ph.D.

Search for recent publications by Lakshmanan Iyer

Research Interests

Computational approaches to solving biological problems: I am interested in applying and developing computational biology methodology, tools and resources to address research problems in collaboration with experimental biologists.

Topics of interest:

• Analysis of expression, regulation and interaction of genes and their products.
• Protein structure modeling, dynamics and docking
• Literature and knowledge base data mining to identify disease markers and targets.
• Statistical analysis of datasets such as high throughput small molecule screens.
• Research Computing: Porting computational biology applications for Tufts research community.

Recent Publications

O’Neill T, Giarratani L, Chen P, Iyer L, Lee C-H, Bobiak M, Kanai F, Zhou B-B, Chung JH, Rathbun GA. Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J Biol Chem 2002;277:16102-15.

Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Mol Cell Proteomics 2003;2:1188-97

Yang F, Vought BW, Satterlee JS, JimSun Z -Y, Watts JL, Walker AK, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol Christine, Iyer LK, Tjian R, Heuvel SV, Hart AC,Wagner G, and Näär AM.An ARC/Mediator subunit required for SREBP gene activation andregulation of cholesterol and fatty acid homeostasis, Nature. 2006 Jun 21. [Epub ahead of print]

Pospisil P, Iyer LK, Adelstein SJ, Kassis AI. A combined approach to data mining of textual and structured data to identify cancer-related targets. BMC Bioinformatics. 2006 ;7(1):354

Chen Kai, Wang K, Kirichian AM, Al Aowad AF, Iyer LK, Adelstein SJ, and Kassis AI.  In silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase–mediated cancer diagnosis and therapy. Mol. Cancer Ther. 2006; 5: 3001-3013.

Pospisil P, Wang K, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI. Computational modeling and experimental evaluation of a novel prodrug for targeting the extracellular space of prostate tumors. Cancer Res, 2007, 67:5

Pospisil P, Korideck H, Wang K, Yang Y, Iyer LK, Adelstein SJ, Kassis AI. Sulfatase 1-mediated precipitation of radiolabeled prodrugs for targeting pancreatic cancer cells. submitted to Cancer Research 2007.