People

Sung-Woo Kim, Ph.D.
Research Assistant Professor
Department of Neuroscience
Office Phone: (617) 636-4050
Lab Phone: (617) 636-3526
Fax: (617) 636-2413
Sung-Woo.Kim@tufts.edu

Search for recent publications by Sung-Woo Kim

Education and Academic / Institution Appointments

• 1989-1994 Ph.D. in Neurobiology, Columbia University, New York.
• 1994-1997 Research fellow in molecular endocrinology, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA.
• 1998-2006 Instructor in Medicine and Psychiatry, Harvard Medical School, Brigham and Women’s Hospital/ McLean Hospital, MA.
• 2007-Present Research Assistant Professor in Neuroscience, Tufts University School of Medicine, Boston, MA.

Awards and Honors

• 1998 Young Scientist Grant Award, American Thyroid Association
• 2000 President Award, New England BioScience Society, Boston
• 2001-2004 Mentored Career Award (KO1), NIDDK, NIH

Research Interests

We focus on:
1) identification of biomarkers of brain diseases such as Alzheimer’s and Parkinson’s diseases
2) studies of biomarker-mediated signal pathways of neurodiseases
3) application of biomarkers for diagnostic purpose and identification of therapeutic drugs using micro/nano-fluidic Lab-on-a-Chip.

Lab Members

Jiwan Kim, Visiting Scientist
Chan Chung, Visiting Scientist

Selected Publications

1. Sangmee Ahn Jo, Ph.D., Eunkyung Kim, M.S., Changsu Han, M.D., Ph.D., Moon Ho Park , M.D., Wonho Kim, Ph.D., Sung-Woo Kim, Ph.D. and Inho Jo, Ph.D. The Mutant Allele (ALDH2*2) of Mitochondrial Aldehyde Dehydrogenase 2 Gene is Protective against the Presence of Mild Cognitive Impairment in Older Korean Men. (2007) J Am Geritri Soc. (submitted).

2. Soohyun Lee, Sung-Woo Kim, and Chong H. Ahn. A Plastic Lab-on-a-Chip for HIV Diagnostics Using RT-PCR and Dynamic Detection. The 10th International Conference of Miniaturized Systems for Chemistry and Life Sciences (uTAS 2006): Proceedings of Micro Total Analysis Systems 2006 (2006); 2: 1432-1434.

3.Hyerhan Jeong, Mi-Soo Kim, Sung-Woo Kim, Kwang-Soo Kim, Wongi Seol. Regulation of tyrosine hydroxylase gene expression by retinoic acid receptor. Journal of Neurochemistry (2006); 98 (2):386-94.

4. Sung-Woo Kim**, Sung-Chul Ho, Seong-June Hong, Kyung Min Kim, Edward C. So, Marcelo Christoffolete, and John W. Harney. A novel mechanism of T3-dependent negative regulation by thyroid hormone receptor, NCoR, and GAGA binding factor on the rat CD44 promoter. Journal of Biological Chemistry (2005); 280: 14545-55 (**Corresponding author).

5. Sung-Woo Kim**, Seung-June Hong, Kyung Min Kim, Sung-Chul Ho, Edward C. So, John W. Harney and P. Reed Larsen. A novel cell-type specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene. Molecular Endocrinology (2004); 18(12):2924-36. (**Corresponding author,).

6. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. Journal of Clinical Investigation (2001); 108(9):1379-1385.

7. Tibor Bartha*, Sung-Woo Kim*, Domenico Salvatore, Balazs Gereben, Helen Tu, John W. Harney, Peter Rudas and P.R. Larsen. Characterization of the 5’ flanking and 5’ untranslated regions of the cyclic AMP-responsive human type 2 iodothyronine deiodinase gene. Endocrinology. (2000); 141 (1): 229-237. (*Equal First Author).

8. Sung-Woo Kim, John W. Harney, and P. Reed Larsen. Studies of the hormonal regulation of type 2 5’-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction. Endocrinology. (1998); 139 (12): 4895-4905.

9. Chen-Yu Zhang, Sung-Woo Kim, John W. Harney, and P. Reed Larsen. Further characterization of thyroid hormone response elements in the human type I iodothyronine deiodinase gene. Endocrinology. (1998); 139 (3): 1156-1163.

10. H. Tu*, S.-W. Kim*, D. Salvatore, T. Bartha, G. Legardi, P.R. Larsen, and R.M. Lechan. Regional distribution of type 2 thyroxine (T4) deiodinase (D2) mRNA in the rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology (1997); 138 (8): 3359-3368. (*Equal First Author).

11. K.H. In, K. Asano, D. Beier, J. Grobholz, P.W. Finn, E.K. Silverman, E.S. Silverman, T. Collins, A.R. Fisher, T.P. Keith, K. Serino, S.W. Kim, G.T. De Sanctis, C. Yandava, A. Pillari, P. Rubin, J. Kemp, E. Israel, W. Busse, D. Ledford, J.J. Murray, A. Segal, D. Tinkleman, and J.M. Drazen. Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. Journal of Clinical Investigation (1997); 99(5): 1130-1137.

12. Sung-Woo Kim, Il-Min Ahn, and P. Reed Larsen. In vivo genomic footprinting of thyroid hormone-responsive genes in pituitary tumor cell lines. Molecular and Cellular Biology (1996); 16(8): 4465-4477.